Pyloric antral inhibition of gastrin release

Inconsistencies and omissions in current explanations for the well known depressions of gastric acid secretion and blood gastrin levels following acidification by antral stimulants are discussed. Evidence is presented which favors a reciprocal sensitivity relationship between the fundic mucosa and the antral G cells, such that blood gastrin levels rise when the secreting fundic mucosa is compromised and acid secretion in response to exogenous gastrin is increased when G cells are depressed or reduced. The functional connections between the two phenomena are considered to be nervous.