Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography.

Background Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease. Objectives To determine the relation between natural AECA levels and prognosis related to coronary artery disease. Methods Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up. Results Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels ( Conclusions After a median of more than 6 years, higher natural AECA levels were associated with less coronary artery disease and lower mortality rates in patients undergoing coronary angiography.