Analysis of Risk Factors for Metachronous Hepatic Metastasis After Rectal Carcinoma Surgery at Stage I to II

Objective To investigate the clinical factors for hepatic metastasis of rectal carcinoma at stageⅠ～Ⅱ.Methods Three hundred and eighty cases of rectal cancer were collected to set up the database.Binary and multinomial logistic regression was employed to indicate the independent factors relating to hepatic metastasis,the regression equation to predict probability of liver metastasis of rectal cancer.Results Multivariate analysis revealed that blood vessel invade(BVI),TMN stage,type of pathology,microvessel density(MDV),adjuvment therapy and circumferential margin involvement(CMI) were independent indicators of the probability of hepatic metastasis of rectal carcinoma at stageⅠ～Ⅱ.Conclusion Patients with early stage rectal cancer,which is complicated with BVI,advanced T phase,high preoperative level MVD,CMI or poor differentiation degree,are apt to develop liver metastasis.They should be given further individualized intensive adjuvant treatment.