Thiophene and tiazolsulfonamidas as antineoplastic agents.

A compound of Formula I: where: -X = Y- is or; R1 is selected from the group consisting of halo, C1-C6 alkyl and CF3; R2 is selected from the group consisting of halo, -NO2, C1-C6 alkyl and CF3; R3 is hydrogen, C1-C6 alkyl, C1-C4 alkoxy, C1-C6 alkyl or halo; R4 is selected from the group consisting of H, halo, C1-C4 alkoxy, C1-C6 alkyl, - COO (C1-C6), C1-C6 alkyl optionally substituted with C1-C4 alkoxy, cyano, C1-C6 , CF3, S-phenyl and pyridinyl; R5 is halo, C1-C6 or C1-C4 alkyl; or an addition salt of pharmaceutically acceptable bases thereof.