Genome-wide Association Study of Colorectal Cancer in Hispanics

Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) with P < 5 × 10 −8 . Most studies have been conducted in non-Hispanic whites and East Asians; however, the generalizability of these findings and the potential for ethnic-specific risk variation in Hispanic and Latino (HL) individuals have been largely understudied. We describe the first GWAS of common genetic variation contributing to CRC risk in HL (1611 CRC cases and 4330 controls). We also examine known susceptibility alleles and implement imputation-based fine- mapping to identify potential ethnicity-specific association signals in known risk regions. We discovered 17 variants across 4 independent regions that merit further investigation due to suggestive CRC associations (P < 1 × 10 −6 ) at 1p34.3 (rs7528276; Odds Ratio (OR) = 1.86 (95% confidence interval (CI): 1.47-2.36); P = 2.5 × 10 −7 ), 2q23.3 (rs1367374; OR = 1.37 (95% CI: 1.21-1.55);