Mesoporous Silica Nanoparticles Are Nanocarrier for Drug Loading and Induces Cell Death in Breast Cancer

Breast cancer is a frequent malignancy in women globally, and it is curable at an early stage. However, the later stage is non-curable with currently available therapy. Because of its high invasiveness and heterogeneity in nature is limiting drug activity. Nowadays, chemotherapeutic molecules are created more side effects; therefore, they need an alternative strategy for overcoming this problem. Natural compounds are biologically active molecules that are prevention of disease with lesser toxicity. Curcumin is an active polyphenolic compound and hydrophobic. In this regard, mesoporous silica nanoparticles are effectively utilized as a nanocarrier for loading various therapeutic molecules, including curcumin and other natural products. The curcumin-loaded nanocarriers are targeted delivery and sustained release at intracellular level then induced cell death effectively. Depending on the conjugate, the natural compounds effectively loading enhances the sustained release from the carrier. Therefore, mesoporous silica nanocarriers significantly play a major role in targeted delivery, sustained release and induce breast cancer cell death.