Asymmetric RNA interfering compositions and use thereof

A duplex RNA molecule interfering asymmetrical consisting of: a non-coding strand, consisting of 19-23 nucleotides, wherein the non-coding strand contains a 3 'and a 5' overhang, and wherein the 3 'overhang consists of RNA nucleotides, and a coding strand, consisting of 14-17 nucleotides, wherein the coding strand is at least 70% complementary to the noncoding strand, wherein the non-coding strand is at least 70 % complementary to a target mRNA; and wherein the non-coding strand and sense strand form a double stranded region of 14, 15, 16 or 17 nucleotide base pairs