Expressions of mutant p53 and Nampt in gastric cancer tissue and their relations with prognosis

Objective: To investigate the expressions of mutant p53 (mutp53) and nicotinamide phosphoribosyltransferase (Nampt) in gastric cancer tissue and their influences on prognosis of the patients. Methods: Immunohistochemical staining was performed for detection of the expressions of p53 (immunohistochemical positive stained p53 proteins are mainly mutant type) and Nampt in specimens of gastric cancer tissues along with the adjacent normal gastric mucosa from 68 gastric cancer patients, and the relations of expression statuses of p53 and Nampt with the clinicopathologic factors and prognosis of the patients were analyzed. ·基础研究·