In situ analysis of FGFR2 mRNA and comparison with FGFR2 gene copy number by dual-color in situ hybridization in a large cohort of gastric cancer patients

Yasutoshi Kuboki,Christoph A. Schatz,Karl Koechert,Sabine Schubert,Janine Feng,Sabine Wittemer-Rump,Karl Ziegelbauer,Thomas Krahn,Akiko Kawano Nagatsuma,Atsushi Ochiai

In situ analysis of FGFR2 mRNA and comparison with FGFR2 gene copy number by dual-color in situ hybridization in a large cohort of gastric cancer patients

2018

Yasutoshi Kuboki
Christoph A. Schatz
Karl Koechert
Sabine Schubert
Janine Feng
Sabine Wittemer-Rump
Karl Ziegelbauer
Thomas Krahn
Akiko Kawano Nagatsuma
Atsushi Ochiai

Background Fibroblast growth factor receptor (FGFR2) has been proposed as a target in gastric cancer. However, appropriate methods to select patients for anti-FGFR2 therapies have not yet been established.

Keywords:

In situ hybridization
Fibroblast growth factor receptor
Cancer
Cohort
Pathology
Copy-number variation
Gene duplication
Biology
Molecular biology
Messenger RNA
Biomarker (medicine)
In situ

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