Tandem Prins cyclization for the synthesis of 1,8-dioxa-3-azaspiro[4.5]dec-2-ene derivatives

Abstract A tandem Prins strategy has been developed for the synthesis of 1,8-dioxa 3-azaspiro[4.5]dec-2-ene derivatives using 5 mol% Cu(OTf) 2 in dichloromethane at 0 °C under mild reaction conditions in short reaction times. This method provides the products in good yields with a diverse substitution pattern.