Antitrichomonadal and other biological effects of sugar hydrazones and phenylosazones

When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro-and dinitrophenylhydrazones a significant inhibitory effect on multiplication ofTrichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a alight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determinedin vivo. Mutagenicity of these compounds was followed with microorganisms and their cytotoxicity with tumor EAC cells. Two of the effective compounds exhibited also a significant mutagenic effect, three of eight compounds had a pronounced cytotoxic effect, three of eight compounds had a pronounced cytotoxic effectin vitro on the EAC cells, in which they inhibited mainly the incorporation of adenine.