PYRAZOLONE: A NEW PROFILE OF BIOLOGICAL ACTIVITIES AND SYNTHESIS

Summary Pyrazolone, a five-membered-ring lactam, is a derivative of pyrazole that has an additional keto (=O) group have been studied extensively owing to their interesting pharmacological activities. This review article covers the most active Pyrazolone derivatives that have shown considerable biological actions such as antimicrobial, antiinflammatory, anticancer, antilipidemic, antiviral, antihypertensive, and antitubercular. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing Pyrazolone moiety that could be better agents in terms of efficacy and safety.