Assessment of Metabolite Concentrations Changes in Rat Brain after Intravenous CDPcholine Injection Using Magnetic Resonance Spectroscopy in vivo

CDPcholine (citicoline, CDPCho) shows beneficial effects in various Central Nervous System (CNS) injury models and neurodegenerative diseases. Previous studies demonstrate conflicting Magnetic Resonance Spectroscopy (MRS) reports regarding the impact of different choline-containing compounds and its doses on brain metabolites. This preliminary study was designed to evaluate concentration changes of brain MR-visible metabolites following intravenous CDPCholine. Twelve healthy rats treated with CDPCholine in three subsequent doses of Igram/kg each were examined using 'H and 31 P MRS in vivo. Following intravenous CDPCholine administration there was a statistically significant increase of the Cho/Cr ratio after first CDPCholine injection. The evidence of CDPcholine influence on brain metabolites has been shown.