Prolongation of skin homografts in rabbits, using cyclophosphamide

Summary 1. Cyclophosphamide can significantly prolong the survival of skin homografts in rabbits. 2. The histologic immune response in the regional lymph node and spleen was suppressed. 3. These results appeared to be a direct and specific effect of cyclophosphamide upon the immune mechanism, and not a nonspecific inhibition arising from a toxic state of the animals.