Original Article Study of the clinical significance of DKK1 in the diagnosis and therapeutic monitoring of lung cancer

To investigate the clinical value of Dickkopf1 (DKK1) in diagnosis of lung cancer and chemotherapy Moni- toring. Methods 127 cases oflung disease patientsas research subjects, according to the nature of the disease, dividedinto the malignant group (n = 67) and benign disease group (n = 60), then choose 60 cases of healthy people as a control group, according to the cancer patients chemosensitivity, divided the malignant group into sensitive group (n = 54) and drug group (n = 13), then detected the target serum DKK1 concentrations using ELSIA double antibody sandwich method and compared. Up Limits of DKK1 of control patients was as a reference value, calculated malignant group, benign disease group and control group DKK1 expression rate; calculated diagnostic sensitivity and specificity of DKK1 of lung cancerby ROC curve areachart. According to the effect of chemotherapy, patients were divided into remission group, stable group and progress group. Results: DKK1 concentration and positive expression rate of malignant group was higher than that in benign group and the control group (P <0.05); area under the ROC curve showed that,malignant group the different TNM stage, lymph node metastasis, distant metastasis,the serum DKK1 concentrations significant differences (P <0.05); sensitive group DKK1 concentrations below resistance group (P <0.05); remission group DKK1 concentration was less than stable group and progress group (P <0.05). Conclusion: DKK1 in lung cancer patients showed high expression, it may be an important marker of lung cancer screening and diagnosis and chemotherapy evaluation.