Antiulcer effect of the N- and O-β-D-glucopyranosides of 5-aminosalicylic acid

Starting from methyl 5-nitrosalicylate (20) the N- and O-β-glucopyranosyl derivatives (24, 28) of 5-aminosalicylic acid were prepared. The LD 50 values of these compounds were determined on mice, and the inhibitory effect of 24 (0.83 mmol/kg) and 28 (1.2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated.