IDENTIFICATION OF THE OCCURRENCE OF HYPONATREMIA IN HOSPITALIZED ELDERLY USING WEAK OPIOIDS

ABSTRACTBackground: Drug-induced hepatitis, also called toxic hepatitis or DILI (Drug Induced Liver Injury),accounts for about 2% of hospitalization cases of jaundice and liver damage is involved in 3-10% of alladverse drug reactions. Cases of hepatic injury associated with ibuprofen use are rare and the frequencyof idiosyncratic hepatotoxicity is small. Objective: To report a case of hepatic injury induced byibuprofen identified in a medium complexity outpatient clinic. Case report: A 48-year-old female patientwas admitted to a Specialized Care Center in the southwestern state of Bahia for a consultation with anorthopedist complaining of low back pain, and ibuprofen and sodium dipyrone were prescribed to relievesymptoms. After 15 days of treatment, the patient returns to the service complaining of arthralgia in theupper limbs, right hand edema, jaundice, coluria, fecal suppura, asthenia and intense pruritus. From theinvestigation of the presented case, viral and autoimmune etiologies were ruled out. Ultrasonography of the total abdomen showed a slight abnormal texture of the liver and gallstones in motion, being suggestive of choledocholithiasis. After evaluation of causality and application of RUCAM, the reaction was classified as highly probable. Conclusions: The hepatic injury shown by the patient has a strong causal relationship with the use of ibuprofen.