Inhibition of cartilage breakdown by isothiazolones
1993
Abstract Isothiazolones and isoselenazolones have been found to inhibit IL-1β induced breakdown of bovine nasal cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, non-peptide lead series approach to the mediation of the chronic cartilage breakdown associated with arthritic disease.
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