Sex differences in VA patients with chronic pain

men (p≤0.05) and women (p<0.05). In the vS, baseline BPND was significantly greater in G-carriers vs. noncarriers in men (p<0.05), but not in women. There were no significant genotype differences in AMPH-induced DAR in the striatum or the vS for either gender. Conclusions: These data indicate that A335G genotype did not predict the magnitude of DAR in normal healthy subjects, but was associated with baseline differences in D2/3 availability in the vS (males only), and in the whole striatum (both genders). Financial support: R01 AA012837, R01 AA010158.