Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

A. Italiano,Nathan Touati,Saskia Litière,Françoise Collin,Philippe Pourquier,Alessandro Gronchi

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

2018

A. Italiano
Nathan Touati
Saskia Litière
Françoise Collin
Philippe Pourquier
Alessandro Gronchi

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.

Keywords:

Trabectedin
Cancer research
Sarcoma
Medicine
predictive value
brca1 gene
Drug
Internal medicine
DNA repair
Oncology

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