Cytologic Aspect of Fibrous Osteodystrophy in a Juvenile Siberian Husky

A 5-month-old intact female Siberian Husky dog was presented for evaluation of severely enlarged maxilla. Abnormalities in CBC, serum chemistry and urinalysis indicated purulent inflammation and renal failure. Cytologic examination of the swollen maxilla showed a mixed population of multinucleated giant cells and round to polygonal to spindle shaped cells either individualized or aggregated. Both type of cells showed moderate anisokaryosis, and anisocytosis, prominent nucleolus or multiple nucleoli, and coarse chromatin. On histopathology maxilla and turbinate were diffusely expanded and replaced by variably dense fibrous connective tissue, and the kidneys showed changes consistent with renal dysplasia. Based on these findings, the diagnosis of fibrous osteodystrophy due to renal dysplasia and fibrosis was made. Despite the supportive care, the dog continued to decline and was euthanized.