Peripheral Oedema due to S-Amlodipine - A Report of Three Cases

S-amlodipine is a stereoisomer of Amlodipine, a dihydropyridine Calcium Channel Blocker (CCB) used in angina and hypertension. This drug is expected to produce a lesser incidence of pedal oedema, as compared to Amlodipine, based on the limited data available from clinical trials. However, conflicting results have been noted with this drug, in relationship to the occurrence of pedal oedema. We report three cases, where the patients either did not recover from pedal oedema, or had a worsening of pedal oedema after substituting S-amlodipine in place of other CCBs that caused pedal oedema.