A cleavable chimeric peptide-R7: enhancing the dual-function of LPS neutralizationand antibacterial properties against MDR E. coli

During the last ten years, the design of new enzyme-free electrochemical sensors based metal oxide nanoparticles has been described. Due to the electrocatalytic activity of these nanomaterials, these sensors allow the sensitive detection of different ions and molecules. They can replace advantageously enzymes due to their higher stability. The presentation will be focused on the use of Kegging type polyoxometallates (POMs) for the detection of nitrite ions1 and of hydrogen peroxide. The association of POMs with single-wall carbon nanotubes (image) allowed the increase of the sensitivity of detection of hydrogen peroxide by a factor of 38.52. The involved charge transfer mechanism will be detailed. Other types of metal oxide nanomaterials such as perovskites will also be presented. A2BO4+δ type perovskite are alternance of perovskite ABO3 and of rock salt AO layers, A being a lanthanide and B a metal. Detection limit of glucose is 0.5 μM and no interference of detection is observed in human serum. The involved charge transfer mechanism will be detailed. This presentation shows the potentiality of metal oxide nanomaterials for biosensing.