Clinical Impact of Apparent Structural and Functional Similarities between Extracellular Vesicles RNA (EVs RNA) and Chronic RNA Viruses

Disruption of nucleoprotein contents of cells can be considerd a reflection of cell stress phase rather than a reflection of the disease state of organs. Disruption of normal cellular protein machinery would occur as a result of cell exposure to stressors. Stressors can be extracellular or intracellular (e.g. infections, malnutrition, obesity, physical or mental exertion and other ecologic factors). Repeated tissue injury results in repeated altered remodeling of damaged tissues and may lead to tissue fibrosis and possibly organ failure (e.g. autoimmune or malignancies). Duration, severity and frequency of cell exposure to stressors have been proposed to exert negative impact on cells; possibly through the different types of extracellular vesicles (EVs) shed by cells involved in each exposure and consequently affect the mechanisms of cell function. These cumulative effects simulate, at least in part, the behavior of chronic RNA viruses (e.g. HCV, Herpes viruses and HIV) which may exert relatively harmless effect and remain dormant within the human body for months and years. We hypothesis that: EVs produced by different types of cells in response to exposure to stress, may behave like persistent self-induced particles as if they were auto-viruses and may need to be neutralized to abolish their proposed role in disease induction and/or progression, or otherwise they might provoke serious diseases.