Identificação de variantes de hemoglobina em doadores de sangue Identification of hemoglobin variants in blood donor

Abstract Hemoglobinopathies are the most common genetic diseases andaffect a great number of individuals in the world, with diverseclinical complications ranging from the almost unnoticeable tolethal consequences. In Brazil the occurrence of hemoglobino-pathies is very frequent and influenced by the ethnical groupsthat are the basis of populations in different regions. Thephenotype may be influenced by environmental and genetic factors Fig. 1 – Distribuicao de variantes de hemoglobinas em hetero-zigose observadas em doadores de sangue apos a combinacaode metodologias de diagnosticoQuadro 1Detalhamento dos fenotipos de Hb observados em amostras desangue de doadores do Hemocentro de Sao Jose do Rio PretoTotal co mperfil de HbanormaisTriagem em pHalcalinoOutrasmetodologiasInteracoes comalfa talassemiaInteracoescomHb Fetal397 amostra sHb AS (284)[71,53%]Hb AS (166)[58,45%](103)[36,26%](1)[0,35%]Hb AD Los Angeles(8)[2,82%]Hb AD Iran(2)[0,70%]Hb A korle-Bu (1)[0,35%]b AH sha ron (3)[1,05%]Hb AC (89)[22,41%]Hb AC (42)[47,19%](47)[52,80%]Outrashemoglobinas (24)[6,04%]Hb AF (4)[16,60%](5)[20,83%]Hb AJ (1)[4,16%]AH(1)[4,16%]A2 aumentado (1)[4,16%](1)[4,16%](2)[8,33 %]Mutantes naoidentificados (9)[37,5 %]