An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research

Fa Wang,Robert L. Johnson,Paul W. Snyder,Marsha DeSmet,James C. Fleet

An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research

2016

Fa Wang
Robert L. Johnson
Paul W. Snyder
Marsha DeSmet
James C. Fleet

Background Animal models are an important tool to understand intestinal biology. Our laboratory previously generated C57BL/6-Tg(Car1-cre)5Flt transgenic mice (CAC) with large-intestine-specific Cre recombinase (Cre) expression as a model to study colon health.

Keywords:

Medicine
Colorectal cancer
Colitis
Beta-galactosidase
Integrases
Genetically modified mouse
Large intestine
Transgene
Cre recombinase
Molecular biology
Hepatology
Internal medicine

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