Basal cell carcinoma or melanoma, that is the question!

Both dermoscopy and in-vivo reflectance confocal microscopy (RCM) demonstrated high levels of diagnostic accuracy for basal cell carcinoma (BCC) diagnosis.(1,2) Although specific dermoscopic criteria have been described, BCC may simulate other benign and malignant cutaneous tumors, with melanoma representing one of the most common differential diagnosis.(3) RCM has been largely employed for both BCC diagnosis and management in in-vivo and ex-vivo settings.(4) However, in few cases, RCM features could be misinterpreted especially by novices leading to delayed surgical excision.