Tritiation of CEP‐1347 at high specific activity using several methods

[Thiomethylenes-3H] CEP-1347 (5) was synthesized by the tritiation of diformyl precursor 3 with NaB3H4 followed by treatment with ethanethiol. [Methyl ester-3H] CEP-1347 (7) was prepared at even higher specific activity by the alkylation of precursor 6 with C3H3I. Copyright © 2005 John Wiley & Sons, Ltd.