Composition of amorphous Canagliflozin and medicinal adjuvants and preparation method thereof

2015 
A composition of amorphous Canagliflozin and medicinal adjuvants and a preparation method thereof are disclosed, the composition comprises the Canagliflozin and two or more than two medicinal adjuvants, the weight ratio of the Canagliflozin and all the medicinal adjuvants is 1:0.1 to 100, the Canagliflozin in the composition is amorphous, and after background peaks of the medicinal adjuvants are taken out, no characteristic peak of Canagliflozin crystals is in an X-ray powder diffraction spectrum of the composition. The composition of the amorphous Canagliflozin and the medicinal adjuvants has good stability and dispersibility, dissolution rate of the Canagliflozin is increased, improvement of bioavailability and body's absorption of drugs can be facilitated, and under conditions of accelerated tests, good physical and chemical stability can be maintained. The preparation method has the advantages of simple operation, low cost, good reproducibility and easy realization, and is suitable for industrial production.
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