Three-Component One-Pot Reactions of 2-Trifluoromethyl-N-nosylaziridine, Primary Amines, and Vinylsulfonium Salts for Convenient Access to CF3-Containing Piperazines
2017
Trifluoromethylated piperazines were readily synthesized with excellent regioselectivity in high yields by the sequential reaction of 2-trifluoromethylated N -nosylaziridine (2-CF 3 - N -Ns-aziridine) with various primary amines, followed by treatment with vinylsulfonium salts, in one pot.
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