Reducing Blood Transfusion in Aortic Surgery: A Novel Approach

Abstract Background We introduced a new algorithm utilising patients own platelet rich plasma and factor concentrates to better manage coagulopathy in aortic surgery under circulatory arrest. This study compares the outcomes of the patients treated with a new algorithm to that of the patients managed with our traditional approach. Methods The data of 247 consecutive patients who had aortic surgery was analysed. 158 patients (Group 1) who were managed with our usual algorithm were compared with 89 patients (Group 2) who were treated with the novel algorithm consisting of utilisation of patients' own platelet rich plasma, fibrinogen and prothrombin cell concentrates. Differences in transfusion, and the ICU stay were analysed. Univariate and Multivariable robust regression analysis were performed. Results In comparison to Group 1, the patients in Group 2 had significantly reduced need for transfusion of for red cells ( (7.9 ± 8.6 vs 3.5 ± 3.8, p Conclusions Using autologous plasma and factor concentrates to reverse coagulopathy in aortic surgery significantly reduces blood product transfusion.