Although maintenance dialysis prevents death from uremia, patient survival and quality of life remains an important issue

Background and purpose: Recognition of some predictive biomarkers can improve management of the patient treated by dialysis. This study was designed to recognize and assess relationship between some hematologic and biochemical markers with morbidity in patient treated with peritoneal dialysis. Materials and methods: In this longitudinal study we enrolled 57 patient with end stage renal disease receiving maintenance peritoneal dialysis in Imam Khomeini hospital from 2002 to 2007. We measured some hematologic and biochemical serum markers regularly and at the time of some morbidities. The statistical comparison of results did by chi-square and t-test. methods. Results: Peritonits was occurred in 41 patients at least 1 to maximum 11 times during the study period. The median of ESR and CRP in this group were significant higher compared with the group of patients without peritonitis (P=0.00) but increasing of ferritin and decreasing of Hb are not significant statistically.In the group of patients with history of peritonitis, ESR, CRP and ferritin were increased and Hb was decreased during th peritonitis period (P=0.00). Other parameter including WBC, PMN, SGOT, SGPT are increased and hematocrite and albumin are decreased in patients with peritonitis but were not significant statistically. Conclusion: These finding indicate ESR, CRP and ferritin increase and Albumin and cholestrole and Hb decrease during morbidity in peritoneal dialysis patients. These results suggests some biomarkers can play role as predictive valve for morbidity in peritoneal dialysis patients.