PLasmablastic lymphoma with coinfection by Epstein Barr Virus and Herpes Human Virus 8: a case report
2019
espanolEl linfoma plasmablastico es una neoplasia agresiva poco frecuente. Se categoriza segun la clasificacion del 2016 de la OMS como una neoplasia linfoide del tipo del linfoma plasmablastico, que lo define como una proliferacion difusa de celulas grandes neoplasicas semejantes a inmunoblastos B, en la cual las celulas tumorales presentan inmunofenotipo de celulas plasmaticas con positividad para CD138, CD38 y MUM-1, siendo negativas o debilmente positivas para CD45, CD20 y PAX-5. Tienen expresion de inmunoglobulinas plasmaticas en hasta 70% de los casos, sobre todo IgG, asi como de cadenas ligeras kappa o lambda. La mayoria de los casos tienen relacion con el virus Epstein-Barr. Presenta un claro predominio por el sexo masculino, y tipicamente se asocia a estados de inmunodeficiencia, sobre todo al VIH. En estos pacientes, la media de edad de presentacion es de 40 anos y la cavidad oral suele ser la mas afectada. EnglishPlasmablastic lymphoma is a rare aggressive neoplasm. It is categorized according to the 2016 WHO classification as a lymphoid neoplasm of the type of plasmablastic lymphoma, which defines it as a diffuse proliferation of large neoplastic cells similar to B-immunoblasts, in which the tumor cells have immunophenotype of plasma cells with positivity for CD138, CD38 and MUM-1, being negative or weakly positive for CD45, CD20 and PAX-5. They have plasma immunoglobulin expression in up to 70% of cases, especially IgG, as well as kappa or lambda light chains. The majority of cases are related to the Epstein-Barr virus. It presents a clear predominance by the male sex, and is typically associated with immunodeficiency states, especially HIV. In these patients, the average age of presentation is 40 years and the oral cavity is usually the most affected.
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