COLON TARGETED DRUG DELIVERY SYSTEMS: A REVIEW

Colon drug delivery system is gaining importance in most of the days because colon is a site where in both local and systemic delivery of drugs can take place. Targeting drugs directly to the colon is advantageous in the treatment of colonic disease such as ulcerative colitis, crohn’s disease and inflammatory bowel disease. This review mainly comprises the primary approaches for colon targeted drug delivery that include use of prodrugs, coating with pH dependent polymers, coating with independent Biodegradable polymers and delivery system based on the metabolic activity of colonic bacteria. Mainly prodrugs include targeted prodrug design and prodrug design targeting enzymes. This colon targeted drug delivery present in limitations and challenges and evaluation of colon targeted drug delivery.