Chapter 18:Comet Assay – Protocols and Testing Strategies

The assessment of a genotoxic hazard of chemicals and pharmaceuticals is an important component of the preclinical safety assessment. Experience with genetic toxicology testing over the past several decades has demonstrated that no single assay is capable of detecting all genotoxic effects. Therefore, the potential for a compound to cause genotoxicity is typically determined through a battery of in vitro and in vivo genotoxicity tests.