Therapeutic effect of Chaiqing Xiaopi Capsule on hyperplasia of mammary gland in rats

Objective To investigate the therapeutic action of Chaiqing Xiaopi Capsule(CXC) on the hyperplasia of mammary gland(HMG) in rats and to analyze the possible mechanism in treating HMG.Methods Seventy clean Sprague-Dawley rats were divided into seven groups including control,model,tamoxifen citrate,Xiaoru Sanjie Capsule,low-,mid-,and high-dose CXC(0.433,0.855,and 1.712 g/kg) groups.After treatment for five weeks,the height and diameter of nipple were measured,the viscera indexes and the levels of progestogen(P),estrogen(E2),prolactin(PRL),testosterone(T),superoxide dismutase(SOD),and malondialdehyde(MDA) in serum were determined,and the pathologic changes in morphology of breast tissue in rats were observed by microscopy.Results The mid-and high-dose CXC could remarkably reduce the diameter and height of nipple,increase the coefficient of thymus and spleen,and decrease the coefficient of uterus and ovaries.It could also increase the levels of E2,P,and PRL,decrease T level in serum,increase the SOD activity,and decrease the content of MDA.Conclusion CXC has obvious therapeutic effect on HMG in rats,and the mechanism may be related to enhancing immunity,regulating sex hormone level in serum,and antioxidation.