[Value of combined detection of GP73 and alpha-fetoprotein in diagonosis of hepatocellular carcinoma].

Objective To explore the diagnostic value of the measurement of serum Golgi protein 73 (GP73) in the diagnoeis of hepatocellular carcinoma (HCC).Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum GP73 in the 81 cases of HCC,71 cases of chronic hepatitis or cirrhosis (CH/LC) and 65 cases of healthy blood donors,and to evaluate the sensitivity and specificity in the diagnosis of HCC through the ROC curves.Results The average levels of serum GP73 in HCC,CH/LC and Normal groups were ( 152.67 ± 33.59 ) ng/ml,( 93.15 ± 20.02 ) ng/ml and ( 58.95 ± 17.29 ) ng/ml.After calculating through the ROC curves,120 ng/ml was set as the optimal cut-off point,GP73 has a sensitivity of 77.80％ and a specificity of 78.00％.Conclusions GP73 as a serum marker in the diagnosis of HCC had a higher sensitivity than AFP,and the combined detection of GP73 and AFP could improve HCC diagnosis,. Key words: Golgiapparatus; Protein 73; Alpha-fetoproteins; Liver neoplasms; Carcinome,hepatocellalar