Response to the Letter by Kattygnarath et al

We want to answer the letter Olesen et al addressed to Circulation: Cardiovascular Genetics after the publication of our report on MOG1 as a new susceptibility gene for Brugada syndrome (BrS). Olesen et al1 screened MOG1 in 23 patients with BrS and in 197 patients with early-onset lone atrial fibrillation, and they identified the nonsense variation c.181G>T (p.E61X) in 4 patients with atrial fibrillation, resulting in a premature stop codon that truncates the protein upstream of the region that interacts with Nav1.5. They also identified this variant in 2 of 488 healthy individuals (ie, in 0.4% of control subjects vs 1.8% of patients). As indicated by Olesen et al, we reported this nonsense variant at the American Heart Association 2009 scientific sessions,2 in an asymptomatic male patient with a type 1 BrS ECG. This variant was thought to be relevant because it had not been found in 100 control individuals. We later found it in 3 other BrS probands, positive or negative for the SCN5A mutation, and in some family members; in addition, we found it in …