Effects of serum amyloid A protein on lymphocytes, HeLa, and MRC5 cells in culture

A major human acute phase protein, the serum amyloid A protein, has been tested in vitro for its effect on lymphocyte proliferation, the formation of E-stable rosettes, as well as the growth of HeLa and MRC5 cell cultures. Serum amyloid A protein has been found to be markedly inhibitory at 30, 100, 200, and 300 μg/mL, and is a very potent inhibitor of in vitro biological functions.Key words: serum amyloid A protein, lymphocytes, HeLa cells, MRC5 cells.