Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry
2000
Using the high performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS) technique, together with established trends from the literature, the structures of metabolites and impurities of amiodarone, an anti-arhythmic drug, have been assigned. By comparing analyses of products of incubation with rat liver microsomes with controls in which glucose 6-phosphate dehydrogenase was omitted, metabolites could be distinguished from impurities. Structures for the two proposed metabolites and four impurities are proposed. Copyright © 2000 John Wiley & Sons, Ltd.
Keywords:
- Analytical chemistry
- Atmospheric-pressure chemical ionization
- Impurity
- High-performance liquid chromatography
- Liquid chromatography–mass spectrometry
- Tandem mass spectrometry
- Direct electron ionization liquid chromatography–mass spectrometry interface
- Chemistry
- Chromatography
- Mass spectrometry
- rat liver microsomes
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