Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a case control study.

Abstract Objectives The aim of this study was to assess paraoxonase (PON1) and arylesterase (ARE) activities and polymorphism in patients with lacunar infarctions. Design and methods The PON1 activity, ARE and lipid profile were determined in 37 patients and 53 healthy individuals. Descriptive and inferential statistics were used to analyze the data. Results A total of 37 patients (20 males and 17 females) were studied. The levels of PON1 activity in patients and healthy individuals were 63.5 ± 46.7 IU/L and 95.5 ± 75.5 IU/L, respectively ( p  = 0.024). The same values for ARE were 54.3 ± 19.3 KU/L for patients and 69.1 ± 29.3 KU/L for controls ( p  = 0.008). Polymorphism in Q192R location shows statistically different presentation in patient group compared to healthy controls with an odds ratio of 3.42 (CI 95%: 1.24–9.44, p  = 0.017). Conclusions According to this study, we suggest that PON1 192R polymorphism may play a minor role as a risk marker for developing lacunar infarctions in a group of Iranian population.