EFFECT OF ISOXSUPRINE HYDROCHLORIDE ON ONSET OF LABOUR IN PREGNANT RATS

The effects on spontaneous labour of Isoxsuprine hydrochloride (I), a I²2-adrenoceptor agonist1 were studied on pregnantrats. Oral administration of (I) from day 13 to 21 of gestation in dose of 2.5 mg/kg/day or higher effectively delayed the onset of labour, slight increase in duration of parturition (DOP) and average weight of pup (AWP) were observed. No adverse effects on the gestating animals or fetuses were noted. The rat model appears to be a simple, reliable and cost-effective method for evaluating uterine relaxants.