P-014 Improvement in Angiographic Transit Times Post Endovascular Vasospasm Treatment in Patients with Aneurysmal Subarachnoid Haemorrhage

Introduction Improvement in cerebral perfusion post endovascular treatment of vasospasm in patients with aneurysmal subarachnoid haemorrhage (aSAH) is typically assessed by comparison of major vessel diameters on digital subtraction angiography (DSA). In this report we sought to assess relative changes in cerebral blood flow by computational DSA transit time (TT) analysis in patients with cerebral vasospasm before/after endovascular treatment. Material and methods A cohort of 28 patients with aSAH were included. Demographic variables, neurological status, Hunt&Hess grade (H&H) were collected. We developed a method to measure DSA TT by colour-coded reconstruction based on DSA contrast intensity. Regions of interest were chosen over major cerebral vessels (Figure 1). The estimated TT included Time-To-Peak (TTP) from 0–100% intensity (TTP 0–100 ,), TTP from 25–100% (TTP 25–00 ), and TT from 100–0% (TT 100–10 ). Paired student t-test was used to compare TT before and after vasospasm treatment. Results There were 85 treatment sessions (44-left ICA; 41-right ICA). All sessions included vasodilator infusion +/-transluminal balloon angioplasty (33 sessions). There was statistically significant reduction in all TT before and after treatment respectively; M 1 -TTP –100 , (2.35 vs. 2.02 sec, p = 0 .001), M 1 -TTP 25-–00 , (2.41 vs. 2.12 sec, p = 0 .001), M 1 -TT 100-– (5.58 vs. 4.66 sec, p = 0 .0001) and A 1 : A 1 -TTP 0-100 , (2.37 vs. 2.01 sec, p = 0 .001), A 1 -TTP 25-100 , (2.4 vs. 2.07 sec, p = 0 .001) and in A 1 -TT 100-10 (5.58 vs. 4.69 sec, p = 0 .012). Post treatment TTs were comparable to the admission TTs (in H&H 1-2 grade). The TT changes corresponded to neurological improvements in all patients, except patients with established ischemic stroke (4 sessions) and poor H&H grades (16 sessions). No correlation was seen between angiographic vasospasm severity (mild/moderate/severe) and TT. Conclusion The DSA TT correlated with improvements in neurological status in patients with clinical vasospasm. TT might reflect a better way to assess vasospasm severity and response to treatment as compared to vessel diameter. This method may serve as a useful indirect technique for cerebral blood flow assessment in the angiography suite. Disclosures A. Ivanov: None. C. Hsu: None. A. Linninger: None. S. Amin-Hanjani: None. V. Aletich: 2; C; Covedien, Codman. F.