Synthesis and anti-inflammatory activities of imidazo [1,2-a] pyrimidinederivatives

Aim:To synthesize and characterize a series of imidazo[1, 2-a]pyrimidine derivatives,and to evaluate their anti-inflammatory activities.Methods:Based on the analysis of the structure of imidazo[1, 2-a]pyrimidine,a series of compounds(5a-5o) substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized.Their anti-inflammatory activities were evaluated by means of xylene-induced ear swelling in mice.Results:Their structures were confirmed by 1H NMR,IR,MS and elemental analysis.It was found that most of the synthesized compounds possessed the anti-inflammatory activity,of which compound 5d,5f and 5l showed the most potent activity.Conclusion:Imidazopyrimidine compounds keep moderate anti-inflammatory activities as compared with that of ibuprofen.