Effect of isosmotic medium with low sodium content on mitochondria of cultured cerebellar granular cells

Experiments with rhodamine-123 showed that incubation of cultured cerebellar granular cells in a medium with NaCl isosmotically replaced with sucrose reduced mitochondrial membrane potential. Elimination of Ca2+ or addition of CoCl2, noncompetitive (MK-801) and competitive (APH) N-methyl-D-aspartate receptor antagonists abolished deenergizing effects of low-sodium solutions.