High-risk HPV clearance and CIN 3 treated with MAL-PDT: A case report

Abstract High-grade cervical intraepithelial neoplasia (CIN) is the cervical cancer precursor and high-risk HPV (human papillomavirus) is strongly related with this disease. The CIN treatment is excision of the transformation zone (ETZ) and, on the other hand, photodynamic therapy (PDT) has been showed a promising treatment. We are reporting a case of a 33-years-old patient with high-grade CIN 3 treated with topical MAL (methyl aminolevulinate) PDT. Was applied 2.5 g of 20% (w/w) MAL cream overnight and the cervix was illuminated twice, with three weeks apart, using a probe with LEDs simultaneously with a cylindrical laser fiber emitting both at 630 nm, with a fluency of 150 J/cm2. CIN 3 and the presence of high-risk HPV virus was eliminated 120 days after the second procedure. There was no recurrence at 6 months follow-up. This case report using MAL-PDT and a different light arrangement with LEDs and laser fiber associated both cured the patient with CIN 3 and eliminated low and high-risk HPV in just two PDT sessions.