Effects of Qingxian Recipe on Expression of Transforming Growth Factors β_1 in Rats with Liver Fibrosis

Purpose: To explore the therapeutic mechanism of Qingxianfang for anti-hepatic fibrosis.Method: Prepare hepatic fibrosis models of bandicoots and divide them into groups marked "normal","control","Qingxianfang" and "colchicines" by making use of CCl_4.After eight weeks of medical treatment,an observation of hepatic fibrosis is carried on by using HE and Masson pigmentation,immunohistochemistry and RT-PCR checking of TGF-β_1,mRNA and protein expression in hepatic tissue.Result: The expression of TGF-β_1 protein and mRNA reduced clearly in treatment group.Conclusion: Qingxianfang is effective for easing the liver damage and hepatic fibrosis condition of bandicoots.The mechanism may be relative to the restraining of TGF-β_1 expression inside the liver.