MP60-13 URINARY NERVE GROWTH FACTOR AS A POTENTIAL BIOMARKER FOR PREDICTION OF TREATMENT EFFICACY AND RECURRENCE IN OVERACTIVE BLADDER PATIENTS

INTRODUCTION AND OBJECTIVES: Metabolic syndrome (MetS) is a common disease in the United States, with more than 20% prevalence.MetShasbeenshown tohavedetrimental effectson thebladder, including significant lower urinary tract symptoms (LUTS), decreased quality of life, and detrusor underactivity (DU). However, the progression and mechanism of disease are poorly understood. A large animal model for diabetic bladder dysfunction was developed with Ossabaw pigs. It is hypothesized thatMetSaffects thebladder in theOssabawmetabolicpigandpossibly humans by causing DU over time, contributing to LUTS. METHODS: A group of 11 Ossabaw pigs underwent dietary modification consisting of a hypercaloric, atherogenic diet for 10months to induce MetS. This cohort was compared to a group of 5 lean pigs. Urodynamic studies were performed at 7 and 10 months after randomization. Bladder pressure and compliance were used to define detrusor underactivity. RESULTS: MetS was confirmed between the two groups by demonstrating increased body weight in the MetS animals, increased systolic and diastolic blood pressure, fasting serum glucose, total cholesterol, but not triglycerides (Table 1). Eleven Metabolic pigs demonstrated decreased bladder pressure at maximum capacity (28.2 4.6 vs. 63.8 6.5 cmH2O, p1⁄40.001) and increased compliance (67.1 7.9 vs. 22.2 3.2 cc/cmH2O, p<0.005). After 10 months on a metabolic diet, the metabolic pigs were found to have demonstrated decreased bladder pressure at maximum capacity (28.2 4.6 cmH2O vs. 45.6 6.1 cm H20, p1⁄40.026) and increased compliance (67.1 7.9 vs. 28.3 3.1 cc/cmH2O, p1⁄40.006) when compared with the 5 lean pigs (Table 2). CONCLUSIONS: Both lean and MetS groups began with similar urodynamic pressures. After dietary treatment, the MetS group exhibited detrusor underactivity, as hypothesized. Diet inducedMetS is associated with, and may be a causal factor in the development of detrusor underactivity in this novel model for diabetic bladder complications.