Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists
1996
Abstract The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H 2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H 2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding sites of both pharmacophores for the dual activity.
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