Optical techniques for advancement of photodynamic therapy: from model experiments to clinical studies

Progress in photodynamic therapy (PDT) requires development of novel protocols. We report on performance of PDT employing chlorine-based photosensitizers and irradiation at wavelengths of 405 and 660 nm with monitoring by fluorescence imaging (FI) and optical coherence tomography (OCT). The study includes numerical simulations, model and animal experiments, as well as clinical monitoring.